Dannyboy
Tim Barrus: Make no mistake about it, the kid’s on fire. The other junkies call him Dannyboy. I do not usually do this — help them make a video to this extent. I usually tell the kids at-risk in Show Me Your Life that I won’t help them with text. Text or narrative or writing has to come from them (personally, I hate writing). I will help with video and audio. That is it. But I am breaking my rule here. Or there would be no video as Dannyboy is passed out on the floor again. The kid has major learning disabilities. I doubt that he has written a sentence in his life. His video is short, but it’s all the attention span he has. I don’t treat junkies. I don’t deal with addiction as a sickness. Mainly because that’s not my job. My job is to facilitate kids at-risk in expressing themselves. I met Dannyboy when I was visiting Los Angeles and staying at the Alta Cienega Motel in West Hollywood, where Danny was living with other night creatures of his kind. No parents. No school. Danny deals drugs, and he’s a thief. When I met him I thought he was most definitely at-risk, and I think that now. The only difference between the Danny then and the Danny now is the cough. I suspect tuberculosis. I am glad to only be on the computer with him (and sometimes his junkie mates), but when we Skype, the coughing is painful to even look at. There has to be something redeeming about this kid. Even if you have to turn over boulders the size of mountains to find it. Danny’s into sports. Even if he does attend most sports events either high on meth or zombied out on heroin. I do not know Daddy’s world. And either do you. Those of you who are shaking your head knowingly, know nothing of this landscape. Stop pretending. I did not know that Danny could focus his head around images that are mainly of the spectators at any given game. He’s curious. But there is something off about the speeds at which the neurological connections here are made. You can put any kind of moral on this story that you want. It’s still Dannyboy who is living it.The skin, Homelessness and Human Immunodeficiency Virus (HIV) The skin is the largest and most visible organ of the body. Maintenance of skin integrity in homeless people with HIV, poses a number of challenges. Because of the nature of HIV it can be difficult, sometimes impossible, to heal open wounds or ulcers once they appear and poor hygiene conditions, frequent exposure to exacerbating factors (cold, moisture), and difficulties in medical access exacerbate the challenges for homeless people with HIV. Approximately 90% of people living with the Human Immunodeficiency Virus (HIV) develop skin changes and symptoms at some stage during the course of their disease. The spectrum of skin changes in HIV infection is quite wide. Skin infections (bacteria, fungi, virus, or yeasts), various rashes, skin cancers, drug rashes and other drug-induced skin changes are all seen. Skin diseases can warn of progression of HIV disease, as many skin diseases are more likely to occur as the white blood cell (CD4) count decreases. Skin problems, however are very common and may not even be related to HIV infection. With improvements in the anti-retroviral treatment of HIV, the skin diseases associated with HIV infection have also changed. With good viral control and preservation of the immune system, skin problems associated with opportunistic infections (infections other than HIV) and many other skin problems associated with HIV have become far less common, less severe and easier to treat. However, maintenance of skin integrity in people with HIV poses a number of challenges, because of the nature of HIV it can be difficult, sometimes impossible, to heal open wounds or ulcers once they appear. [http://ibmi.mf.uni-lj.si/]. The symptoms can be ranged into three major groups:
1. Most frequent DermatosesSeborrheic Dermatitis (SD) Seborrheic dermatitis (SD) is without doubt the most common dermatosis in HIV-infected patients and is often the only sign of infection occurring in up to 50% of cases. Clinically SD is characterized by a mild to severe erythema with irregular shape, whitish or yellowish scales and a greasy appearance, involving the seborrheic skin regions: the scalp, temples, retroauricular folds, outer parts of the ears, eyebrows, eyelids, glabella, nasolabial folds, and the midline areas of the chest and back. Less frequently intertriginous spaces are involved and widespread lesions may occur. The course is usually chronic. The histopathologic findings are similar to those seen in non HIV-infected individuals. Although SD is always associated with a constitutional seborrheic state and the clinical findings worsen as the disease progresses, and clear as the immune situation improves, this is due to infection to Pityrosporum ovale or Pityrosporum orbiculare. The treatment is essentially local with shampoos containing imidazoles, corticosteroid creams and hygienic measures. Oropharyngeal Candidiasis (OC) Candida albicans is a facultative pathogenic saprophyte and in 60% of normal individuals colonizes the oropharyngeal tract, but in HIV-seropositive patients this may be a valuable marker indicating a compromise of defense mechanisms of the mucosa. Oral candidosis is the most common infection in HIV-infected patients. It is evident that this infection can also be located on other mucosal surfaces like the gland, the coronary sulcus of penis, the vagina or anus, and even in the cutaneous folds and nails, but the relation with AIDS is more difficult to interpret. Disseminated candidiasis in severely immunocompromised HIV-infected patients has rarely been reported, but it is usually fatal. Clinically there are small white lumps which, when removed, leave an underlying erythematous base located on the buccal epithelium of the cheeks, gums, palate or of tongue. In severe cases, extension to the pharynx or to the oesophagus may occur and erosive complications commonly cause severe symptoms resulting in inadequate food intake. The treatments are always deceiving due to the frequent relapses despite the good immediate effects. Therefore a simultaneous local and oral treatment with flutrimazol, itraconazol, piroxolamin or fluconazol has to be used. Condyloma Accuminatum (CA) After SD and OC condyloma accuminatum (CA) is the third most common cutaneous affection in HIV-infected patients, detected in more then 30% of the seropositive individuals. The clinical patterns that can be seen comprehend all the spectra known. In the early HIV disease, the clinical manifestations, clinical course and response to treatment are not unusual. With moderate or advanced immunodeficiency, the HPV lesions may become confluent, much more numerous, unresponsive to usual treatment, and may appear in unusual places. Unfortunately, no therapy has been devised to eradicate HPV entirely; thus it is necessary to use a combined local treatment. A variety of antimitotic agents are widely employed like podophyllin resin, purified podophyllotoxin or 5-fluorouracil. Surgery, cryotherapy, electrocoagulation, lasertherapy, and intralesional interferon-alpha are also standard measures used for HPV infection. Recently new topics, such as imiquimod or 3% cidofovir ointment, have been successfully used. Herpes Simplex (HSV) There are two types of herpes simplex viruses. Herpes simplex I usually causes recurrent blisters around the nose and mouth which are commonly known as 'cold sores'. Cold sores are often triggered by sun exposure, infections such as colds and flu, and being 'run down'. Herpes simplex II is the main cause of herpes sores on the genitals. Herpes sores can, however occur anywhere on the skin. Normally herpes lesions heal within seven to fourteen days. The outbreaks of sores can recur, and usually become fewer and further apart over time. In HIV, herpes simplex may recur more frequently, take longer to heal, be more severe and widespread or occasionally cause longstanding painful ulcers. One commonly misdiagnosed condition is herpes simplex ulcer infections, especially perianal herpes. Because of their location these ulcers can be mistaken for stage II or III pressure ulcers. Although continued unrelieved pressure to the lesions will certainly lead to wound deterioration regardless of etiology, treatment of herpes must include pharmaceutical management. Because medication is critical to healing it is of paramount importance to quickly recognize and treat herpes. To distinguish perianal herpes from pressure ulcers, with herpes there is generally more than one lesion and these lesions are usually distributed bilaterally. Also, herpes ulcers are more painful than pressure ulcers of similar depth, and aggressive pain management is often required. Finally, herpes ulcers will not respond to conventional treatment for pressure ulcers. The onset of herpes is usually preceded by a burning and stinging sensation, then little fluid filled 'blisters' appear, which break down and crust over before healing. Topical creams are available for cold sores. For more severe episodes, or frequently recurrent or persistent sores there are several medication available to both treat and prevent these sores. The treatment of choice for the HSV infection is Valaciclovir, an aciclovir prodrug, with a better oral availability. The use of a topical antiseptic may help to reduce the risk of secondary bacterial infection. In severe HSV infection, possibly resistant to aciclovir, systemic phosphonoformate (Foscarnet) may be considered. Kaposi's Sarcoma (KS) KS is a vascular neoplastic disorder and it is observed much more frequently in homosexuals than in intravenous drug users. KS is caused by the infectious agent HHV-8 (Human Herpes virus Type 8) that has been shown to be transmitted sexually. The prevalence in Spain does not exceed 6% of the HIV-infected persons, contrary to what it happens in most countries worldwide where 11% of seropositives can be observed, though this prevalence has dropped significantly. The treatment of this neoplasm has been based on Interferon alpha. However, at present the combined treatment with two virostatics and a protease inhibitor (HAART) is recommended. Dermatophytosis Up to 20% of HIV-infected persons have dermatophyte infections. This prevalence is similar to that seen in HIV non-infected individuals.
2. Aggressive DermatosesPractically all the dermatological pathology can be observed during the evolutionary stages of AIDS. Syphilis (S) Syphilis is quite frequent in patients with HIV infection, with a prevalence of 18-30%. The symptoms of this oldest and best-known sexually transmitted disease in AIDS patients are less characteristic and thus more difficult to diagnose. Atypical clinical and serological findings are frequent. Examples include rapid progression from the primary chancre to the later stages of S. maligna and widespread gummata. The central nervous system manifestations are more frequent and more severe. The Treponema pallidum has never shown resistance to penicillin and continues to be the treatment of choice. Cutaneous Leishmaniasis (CL) The main area of overlap is Southern Europe, especially Spain. The clinical manifestations, though really aggressive, are not displaying necrosis. The lesions are situated in exposed areas, but the inoculation point is sometimes undetectable. The granulomatous lesions are usually spreading. Making a smear of material from the sore and staining it with Giemsa on a microscope slide can confirm the infection by demonstration of the parasite while histopathology confirms histiocytes full of Leishmania with lymphocytic reaction that possibly facilitates the extension of injuries and even of the scattering. The treatment with pentavalent antimonials is efficient. Necrotizing Folliculitis (NF) All the pyogenic bacterial infections are commonly encountered in HIV patients with a prevalence of 3-11% of cases. Much more rare is the NF that is manifested as suppurative or abscess-like lesions with serohematic and blackish scabs developing in 2-3 days from isolated pustules. The lesions may be scattered anywhere on the skin. Generally, there is not a defined bacteriology, and the healing is slow and unaesthetic. NF is treated with the application of topical antiseptics with good results, but in general it resolves with unaesthetic scars. Necrotizing Gingivitis (NG) A mixed flora like the fusospyrochetae complex, candida, gram-positive cocci, herpes virus, cytomegalovirus, and other organisms may cause acute necrotizing gingivitis in immunocompromised host. The clinical manifestations, including gingival soreness, bleeding and halitosis may develop into necrosis and destructions with loss of teeth and further functional problems. There is often enlargement of the cervical lymph nodes with pyrexia and malaise. The treatment is complicated because to the topical antiseptics we have to add antivirals like valaciclovir, metronidazole or penicillin depending on the gravity and the etiology. Herpes Zoster (HZ) The rash of herpes zoster (shingles) is due to reactivation of the chickenpox virus, which has lain dormant in the body since childhood. Pain often precedes a blistering and later a crusty rash appears in a band like pattern. Shingles usually only involves one side of the body. It commonly involves the trunk, or less often an arm, leg, or region of the face. Development of shingles may be the first clue that someone is infected with HIV and that their immune system has been weakened. This painful condition can last for several weeks and occasionally spreads to other parts of the body. Pain may persist for a while after the skin has healed due to inflammation of the nerves. Several oral anti-viral medications are helpful particularly when started very early after onset of shingles (within 3 days). Early treatment can reduce the severity and duration of pain associated with shingles. Topical lotions may also help symptoms and discomfort. There are also good treatments available for pain should it occur. According to the few publications, the prevalence oscillates between 6 and 9% of HIV-infected persons. HZ in HIV-infected patients is more serious than similar infections in immunocompetent hosts, because painful atrophic scars, persistent ulcerations, multidermatomal involvement, recurrent zoster infections, and secondary episodes of varicella may be seen. Severe pain and persistent postherpetic neuralgia may also develop. The treatment is with one of the thymidine kinase inhibitors, such as acyclovir, valacyclovir, and famcyclovir. Resistant cases require treatment with intravenous application of foscarnet. Molluscum Contagiosum (MC) MC is usually a benign viral infection. However, in immunocompromised patients it may become widespread, disfiguring and unresponsive to treatments. Sometimes other cutaneous disorders (cryptococcosis, pyogenic granuloma, keratoacanthoma, basal cell carcinoma) can mimic Molluscum contagiosum infection, consequently a biopsy is often necessary. MC infection is often accompanied by other viral infections, especially by papillomavirus. The usual method of treatment is curettage, but due to the bleeding that can be produced, the cryotherapy and, recently, the cydofovir are advisable. Scabies Scabies may be sexually transmitted and it is one of the most frequent skin disorders to develop in HIV-infected patients. Scabies may have a number of different clinical manifestations in seropositive individuals, ranging from classic features to crusted (Norwegian) scabies in which a great number of mites are present and the itching is reduced. Scabies in HIV-infected patients may mimic psoriasis, atopic dermatitis, seborrheic dermatitis, lymphomatoid papulosis, and insect bite reactions. The diagnosis is confirmed by examination of scrapings, which demonstrates mites and eggs. Treatment is usually similar to that used in immunocompetent hosts, though several applications of a scabicide may be necessary. It is important that all partners should be treated simultaneously. Papular Pruritic Eruption (PPE) More and more frequently the PPE, an extremely pruritic dermatosis characterized by red or skin-colored, non-confluent micro-papules on a xerotic skin, involving widespread areas, most commonly the trunk, extremities and folds, can be observed. Clinically and histologically, PPE is similar to eosinophilic papulosis of Ofuji, and in the early stages can easily be confused with scabies. The classical therapies are systemic antihistamines, oral prednisone, and topical corticosteroid preparations, but the treatment that seems to be more effective is the exposure to ultraviolet B phototherapy. 3. Exceptional DermatosesThe list in this group could be very long, but we will name only the lesions that may be more significant to suspect the HIV infection. Psoriasis (P) There are scores of descriptions ranging from the transitional whitening with the first symptoms of HIV infection to appearance of the first outbreak after the infection in an individual who has never before had a clinical disease. Nevertheless, nowadays the publications about complicated psoriasis are more frequent in view of the intensity, frequency and extension of the outbreaks, or due to the associated symptoms like arthritis, erythroderma or inverted psoriasis. The therapy depends on the extension and the associated symptoms of the disease. The existing hematic and hepatic changes limit the systemic treatment. The use of psoralen and ultraviolet A therapy is also effective. Oral Hairy Leukoplakia (OHL) This clinical manifestation is detected in about 2.5-10% of cases, even though the incidence of this disorder is decreasing in HIV patients as a consequence of HAART (highly active anti-retroviral therapy) like other cutaneous manifestations of HIV infection. Most commonly, OHL is manifested as corrugated, whitish and asymptomatic plaques situated along the lateral borders of the tongue, rarely bilaterally. With the electron microscopy papilloma virus and Epstein-Barr virus have been detected in the lesion. The most practical treatment is the cryotherapy, though treatment is not always indicated. Prurigo The etiology of the process is not fully known. The clinical and histopathologic findings may resemble classic prurigo nodularis found in immunocompetent hosts. Nevertheless, prurigo seems to be a reaction pattern that may be associated with some bacterial or viral infections, especially in the anus area, secondary to HIV infection. Treatment is mainly directed at suppressing the itching and avoiding secondary infections. Recently thalidomide has been shown to be effective. Medical and Cutaneous Disorders Associated With Homelessness: Skin Diseases in the HomelessAlexander J. Stratigos, MD, Andreas D. Katsambas, MD, Department of Dermatology, University of Athens School of Medicine, Andreas Sygros Hospital, Athens, Greece http://www.medscape.com/viewarticle/455637_3 Cutaneous disease is a frequent cause of morbidity in the homeless. Several skin conditions, both infectious and noninfectious, have been described in the homeless population including trauma, cellulitis, pyodermas, impetigo, gas gangrene, tinea infections, leg ulcers, stasis dermatitis, immersion foot, frostbite, erythromelalgia, pellagra, scurvy, scabies, pediculosis, seborrheic dermatitis, eczematous dermatitis, rosacea, and pruritus. The incidence of skin disease is largely determined by a complex set of factors, namely geographic area, climate, living conditions, access to primary medical care, and coexistent medical conditions. Additional factors that are intrinsically related to homelessness, e.g., malnutrition, exposure to hazardous environments, and psychiatric illness, may have a negative impact on the extent and severity of skin disease. Many of the skin diseases of the homeless are easily diagnosed and treated, but because of the limited access of the homeless to health care resources and the high prevalence of mental illness and alcoholism in this population, homeless persons are likely to neglect skin care until their condition becomes disabling or even life-threatening. Several studies have reported an increased incidence of foot problems, primarily superficial fungal and bacterial infections. In a cohort of 142 homeless men staying overnight in a major Boston shelter over a period of 3 months, 38% had tinea pedis, 20.4% had pitted keratolysis of the feet, and 15.4% had toenail onychomycosis. These diseases are usually related to poor foot hygiene, inadequate footwear, and excessive moisture. Overcrowding in shelters may also increase the risk of cutaneous infections due to exposure to potential pathogens. Tinea infections are quite common in the general population as well, but in homeless people they often represent a portal of entry for fungal and bacterial pathogens that, in the setting of compromised skin care, may lead to more serious or severe infections. Bacterial infections, such as cellulitis and pyodermas, are frequent causes of hospitalization among the homeless. In a survey of admissions to the inpatient dermatology service of a New York municipal hospital, 46% of the admitted patients were street-living or shelter-based homeless and almost one half of them (48%) were diagnosed with cellulitis or other skin infections. Immersion foot (trench foot) is another problem seen with increased frequency among the homeless population. It results from cutaneous injury by water absorption in the stratum corneum of the skin and it is seen more often in street homeless due to improper footwear, prolonged exposure to moisture, and long periods of walking and standing. The syndrome of immersion foot can be exacerbated by peripheral neuropathy, peripheral vascular disease, and the use of tobacco or other vasoconstrictive drugs, e.g., cocaine. Infection or ischemic injury may complicate this condition, requiring antibiotics or surgical treatment. Parasitic infestations of the skin are seen frequently in the homeless population, with scabies and pediculosis being the most prevalent. Recently, an increasing incidence of infection with Bartonella quintana, the etiologic agent of trench fever, has been observed in the homeless and is presumably transmitted through body lice. B. quintana endocarditis and bacteremia have been reported in homeless patients living in downtown Seattle, Oregon, and Marseille, France. In addition, prospective serologic studies have found antibodies to B. quintana in 25%, 30%, and 54% of the homeless population in Seattle, Marseille, and downtown Paris, respectively, compared with only 2% of the control group. In the latter study, the serologic profile suggested a recent or evolving B. quintana infection in 25% of patients with positive serologies. Independent risk factors associated with a positive serology include the age of patients (adjusted relative risk, 2.9 for age >40 years) and the duration of homelessness (adjusted relative risk, 3.0 for ≥3 years of homelessness). An association between B. quintana infection and body lice infestation has been shown, although, in multivariate analysis, the number of previous episodes of body pediculosis was not a risk factor for a positive B. quintana serology. It is possible that the total duration of infestation is the main risk factor, as opposed to the number of new infestations by body pediculosis. The consequences of this high seroprevalence of B. quintana in the homeless population is yet undetermined in terms of its related morbidity and mortality. B. quintana has been recently identified as a significant cause of blood-culture negative endocarditis, and, since heart disease is a major cause of death in homeless people, there could be a possible link between B. quintana infection and cardiac disease in this population. Aside from this hypothesis, current evidence suggests that prolonged homelessness is a major risk factor for B. quintana infection and that every homeless person with body lice infestation should be considered for serologic screening for B. quintana. Common skin dermatoses, such as psoriasis, seborrheic dermatitis, and atopic dermatitis are also seen in the homeless population. Although their prevalence is not exactly known, it does not appear to differ from that of the general population. It is possible that the severity and extent of these diseases is greater because of poor hygiene conditions, frequent exposure to exacerbating factors (cold, moisture), and difficulties in medical access. Homelessness in The United States of AmericaThe human right to housing, travel and migration as a part of individual self-determination rather than the human condition. The Declaration, an international law reinforcement of the Nuremberg Trial Judgements, upholds the rights of one nation to intervene in the affairs of another if said nation is abusing its citizens, and rose out of a 1939–1945 World War II Atlantic environment of extreme split between "haves" and "have nots."
Homeless people face many problems beyond the lack of a safe and suitable home. They are often faced with many social disadvantages also, reduced access to private and public services and reduced access to vital necessities:
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United States of AmericaWARNING: Explicit Imagery and Colloquial Language Human Immunodeficiency Virus (HIV) Acquired Immune Deficiency Syndrome (AIDS)
The link between homelessness and HIV/AIDS: The Centers for Disease Control in Atlanta and the United Nations in NYC estimate that there could be as many as a million homeless people with HIV in North America, and as many as ten million homeless people with HIV in the rest of the world.
There will not be a cure for AIDS until people in specifically the United States begin to understand that it didn’t go away. It’s still out there. Countries in the southern part of Africa still have the worst part of the pandemic. We can’t get medications to all these people. Americans have convinced themselves that AIDS no longer means them. Until it means them, there will be no cure, and millions of people are going to die.
The United States Trade Mission to the WTO (the loudest voice at the WTO denouncing countries that treat their own people) is supervised by the Department of Commerce. An agency whose chains are yanked at regular intervals by Big Pharma (the profits of antiviraldrugs are in the tens of billions) whose International Conglomerates make political donations to political candidates who pledge to enforce the pharmaceutical copyrights of the WTO against such nations as Brazil and India.
"AIDS Crawling Up My Spine"
I can not say that on the night we should go and touch the stars. The stars are sneaky. They infect my bones with a madness that shocks the body and is not yet awake. My eyes bulged with electric chairs and AIDS crawling up my spine. Azalea stones stuck in my throat and ants are walking from my eyes. With two twisted strands of razor wire. Then, in a solemn choice we naked as a dog. Moving about the city as a hebephrenic schizophrenia licked ass on for lunch. |







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